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Lack of core 1-derived mucus O-glycosylation alters gut length.

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posted on 09.01.2014, 03:37 by Felix Sommer, Nina Adam, Malin E. V. Johansson, Lijun Xia, Gunnar C. Hansson, Fredrik Bäckhed

(A) Representative gastrointestinal tracts of wild type (WT) and TM-IEC C1galt-/- (KO) mice. (B) Length of the small intestine and colon of wild type (WT) and TM-IEC C1galt-/- (KO) mice raised in the presence (CONV-R) and absence of bacteria (GF) as well as with or without injection of tamoxifen to induce Cre recombinase-mediated loss of core 1-derived mucus O-glycosylation (n = 7-16 mice per group; Data shows mean ± SEM; ** p<0.01, *** p<0.001).

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