Figure_1.tif (1.53 MB)
L-sel modulates atherosclerosis development.
figure
posted on 2011-07-08, 02:15 authored by Izabela Rozenberg, Susanna H. M. Sluka, Pavani Mocharla, Anders Hallenberg, Pierre Rotzius, Jan Borén, Nicolle Kränkel, Ulf Landmesser, Lubor Borsig, Thomas F. Lüscher, Einar E. Eriksson, Felix C. TannerRepresentative images of aortas stained with Oil-Red-O (ORO). Atherosclerotic lesion area is expressed as percentage of total aortic area. Compared to ApoE−/− controls, there is an increased atherosclerotic burden in A) 12 week old ApoE−/− L-sel−/− animals after 6 weeks of HCD (n = 11–15; *p<0.05); and B) 6 month old ApoE−/− L-sel−/− animals after 6 months of a normal diet (n = 5–9; *p<0.05), but not C) 18 week old ApoE−/− L-sel−/− animals after 12 weeks of HCD (n = 10–15; p = n.s.).
