Kidney histology.

Kidney histology in control animals as well as in animals where no histological changes were seen at (a) 10x magnification and (b) 40x magnification. The glomeruli are normocellular, with open capillary loops. No signs of segmentalization, necrosis or sclerosis were seen. The tubular, interstitial, and vascular compartments were all without histological changes, no signs of necrosis or inflammation were noted. The histological changes associated with the group receiving 150 MBq at 12 months are shown at (c) 10x magnification and (d) 40x magnification. The changes were localized to the glomeruli. These displayed focal signs of segmental sclerosis and segmentalization of the glomeruli, indicating cellular injury to the mesangium and glomerular capillaries. Edemtatous closure of the capillary loops was noted. Furthermore, the nuclei displayed degenerative changes with polymorphism and nuclear fragmentation, potentially indicating detrimental radiation effects. In a fraction of the glomeruli, signs of segmental fibrinoid necrosis were seen, again underscoring acute injury to the glomeruli. Tubules, interstitium and vasculature showed no signs of injury in these tissues. Staining by standard hematoxylin and eosin. The glomeruli are depicted with”G” and the distal tubules with”DT”.