Kaplan-Meier overall survival curves of breast cancer patients and their expression of the Bak protein.

Kaplan-Meier analysis plotting the survival curve of 225 cases of breast cancer with the expression of Bak and clinicopathological characteristics with statistical significance being assessed using the log-rank test. (A) Kaplan-Meier curves showed worse overall survival rates for breast cancer patients with low Bak expression compared with patients with high Bak expression (P = 0.018). (B) Patients with high Bak expression had slight but not significant higher overall survival rates than those with low Bak expression in Luminal subtype (P = 0.23). (C) Patients with high Bak expression had slight but not significant higher overall survival rates than those with low Bak expression in HER2 subtype (P = 0.48). (D) Patients with high Bak expression had a comparable overall survival rate compared with those with low Bak expression in Basal-like subtype (P = 0.41). (E) Patients with high Bak expression had significantly higher overall survival rates than those with low Bak expression in Luminal plus HER2 subtypes (P = 0.01).