Figure_4.tif (231.27 kB)
K118I/K120P CD28 binds CD80 with high avidity in the absence of TCR signaling.
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posted on 2014-02-24, 03:32 authored by Mariano Sanchez-Lockhart, Ana V. Rojas, Margaret M. Fettis, Richard Bauserman, Trissha R. Higa, Hongyu Miao, Richard E. Waugh, Jim MillerCell frequency adhesion of CD28-deficient, DO11.10 T cells retrovirally transduced with WT CD28-YFP or K118I/K120P CD28-YFP to control beads (None) or beads coated with CD80 in the absence (Unstim) and after (Anti-CD3) stimulation. Cell adhesion data are presented as mean ± SD of the adhesion frequency for individual cells (25 impingements each; n = 6–7 for control beads and 12–14 for CD80-Fc beads; p values for t tests between samples are shown).
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BiochemistryproteinsImmune system proteinsProtein interactionsprotein structureT-cell receptorsTransmembrane proteinsBiomacromolecule-ligand interactionsMacromolecular assembliesbiophysicsimmunologyImmune cellst cellsImmune responseimmunomodulationMolecular cell biologySignal transductionMechanisms of signal transductioncrosstalkMembrane receptor signalingImmunologic receptor signalingSignaling in cellular processesTransmembrane signalingcell adhesionComputer modelingComputerized simulationscd28bindscd80aviditytcr
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