Intestinal specific expression of <i>xbp-1</i> is sufficient to rescue sensitivity to the PFT.

<p>Sensitivity to Cry5B was compared among wild-type N2, <i>xbp-1(zc12)</i>, <i>xbp-1(zc12)</i> transformed with <i>app-1::GFP</i>, and <i>xbp-1(zc12)</i> transformed with <i>app-1::xbp-1</i> animals using a plate feeding assay. (A) The health of the worms (details in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000176#s4" target="_blank">Materials and Methods</a>) was evaluated after 72 hours on 25% Cry5B-expressing <i>E. coli</i>. Three and six independent lines of <i>app-1::GFP</i> and <i>app-1::xbp-1</i> were used, respectively. Data are mean and standard deviation of three experiments. (B) Images comparing the health of wild-type N2, <i>xbp-1(zc12)</i>, <i>xbp-1(zc-12) app-1::GFP</i>, and <i>xbp-1(zc-12) app-1::xbp-1</i> animals on 25% Cry5B plates for 72 h. Scale bar is 0.2 mm.</p>