Interactions at the cytosolic site.
figure
posted on 2015-10-20, 03:50 authored by SanthoshKannan Venkatesan, Kusumika Saha, Azmat Sohail, Walter Sandtner, Michael Freissmuth, Gerhard F. Ecker, Harald H. Sitte, Thomas StocknerInteraction network at the cytosolic side (a) in the outward-facing and (b) the intermediate state. (c) Time evolution of the salt bride between E192 and K290. The transporter moves only after opening of the salt bridge.
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substrate uptakemechanismImpaired transportaspartate transporter GltPhchange destabilized cytoplasmichomolog transporter GltPhPyrococcus horikoshiiNa 2 siteNa 2 Sodium Binding Site Glutamate homeostasisenergy hypersurfaceCentral Stepsreconstituted proteoliposomesT 308.Uptake experimentscrystal structuresNa 2 sodium binding siteion gradient conversionside chain rotationglutamate transporter EAAT 3glutamate transporterSubstrate Transportsodium binding
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