In vitro characterization of S. aureus synbody.

(A) Structure of S. aureus synbody. (B) Bacterial growth of S. aureus over time after treatment with peptides or synbody. Measurements were taken hourly. Data points represent the average of three independent experiments. Starting S. aureus concentration is ∼2×10⁵ CFU/mL. (C) Test of lytic activity of lytic peptide and synbody. S. aureus was grown until ∼1.7×10⁹ CFU/mL and the peptide or synbody was added to the final concentration of 100 µM at time zero. Data points represent the average of three independent experiments.