In silico analyses revealed complex genomic architecture in regions of nonrecurrent rearrangement.

(A) The ∼3 Mb surrounding the PLP1 gene and (B) the ∼4 Mb surrounding the MECP2 gene on the X chromosome contain numerous LCRs in various orientations [33],[106]. LCRs are represented by the colored block arrows, and like LCR copies are designated by color and letter for a given sequence. Orientation is depicted by the direction of the block arrow.