Immunoproteasome Deficiency Alters Content of Stress Proteins after ONC.
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posted on 2015-05-15, 03:27 authored by Nathan J. Schuld, Stacy A. Hussong, Rebecca J. Kapphahn, Ute Lehmann, Heidi Roehrich, Abrar A. Rageh, Neal D. Heuss, Wendy Bratten, Dale S. Gregerson, Deborah A. Ferrington(A and B) Protein was isolated from WT, L2, or L7M1 retinas at the indicated time points after ONC. Results are the optical density of PTEN, p-Akt/Akt, and p-S6K1/S6K1 (A), or Bcl-2 and Bax (B) protein content. Data is shown relative to each mouse strains’ control (day 0) and represent the mean ± S.E. of 3–9 mice/group. (*, p≤0.05 by one-way ANOVA with Dunnett’s post-test compared to the ‘day 0’ values or (^, p≤0.05 by one-way ANOVA with Dunnett’s post-test compared to the ‘day 2’ values).
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inducible expressionWT miceWT retinaspigment epithelialptenimmunoproteasome subunits showapoptotic responseimmunoproteasome modulatesimmunoproteasome subunitsigfdisease pathwaysRPE cellsnerve crushMECLnfstudy linkskooxidative stressImmunoproteasome Deficiency ProtectsLMP 7canonical roleantigen presentationoncprotein levelsOptic Nerve Crushinsulin growth factorAkt cell survival pathway
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