Illustration of biological function modules that were affected by drug combinations and were significantly implicated in the regulation of cell apoptosis (false discovery rate <0.05).

A. An apoptosis regulatory module affected by the 2-drug combination of celecoxib and silibinin; B. Apoptosis regulatory modules affected by the 2-drug combination of curcumin and silibinin; C. An apoptosis regulatory module affected by the 2-drug combination of curcumin and celecoxib; D. An apoptosis regulatory module affected by the 3-drug combination of curcumin, celecoxib, and sulforaphane; E. Apoptosis regulatory modules affected by the 3-drug combination of curcumin, celecoxib, and silibinin; the yellow node represents a network target that is involved in the regulation of cell apoptosis.