Hypothetic model for CYP6d5, CYP6a8 and CYP12d1 involvement in caffeine metabolism pathway in Drosophila melanogaster.

In male adult fly bodies, caffeine is degraded into 4 major metabolites: theobromine, M2, paraxanthine and theophylline. CYP6d5 and CYP12d1 seem to metabolize caffeine in theobromine and M2 metabolite, respectively. The metabolism of theobromine and theophylline into unknown secondary metabolites may be controlled by CYP6a8 whereas the M2 degradation could involve cooperation between CYP6a8 and CYP6d5.