Human beta-defensin 3 is up-regulated in the skin of leprosy patients with Type 1 reactions.
Skin biopsies from leprosy patients with Type 1 reactions (T1Rs) and leprosy patients without T1Rs (Controls) were assessed for their expression hBD2 and hBD3 as measured by qPCR. The skin of patients with T1Rs showed non-significantly elevated (A) hBD2 expression and a significant increase in (B) hBD3 expression. (C) Cellular infiltration in the T1Rs and the Controls show no significant differences. For the statistical analyses, values were first converted to a Gaussian distribution by taking their square and subsequently an un-paired t-test was performed. *p<0.05 is considered significant.