G-ratio of 15 month-old wt and tg PLP-α-syn sciatic nerve sections.

The investigation of myelin thickness by calculating the G-ratio (inner axon diameter/outer axon diameter) did not detect differences between tg PLP-α-syn and wt animals in axons thinner than 5 μm, axons between 5 μm and 8 μm and axons between 8 μm and 12 μm (p = 0.1095). Ultra-thin sections of wt and tg PLP-α-syn sciatic nerve tissue have been labeled with toluidine blue, the measurements were performed in microphotographs with 100x magnification. n = 3 animals, 300 fibers of equal distribution analyzed per animal, data represent mean values ± S.E.M.