GPNMB levels in CSF and brain of CBE-treated mice.

(A) CBE (100 mg/kg, i.p) was injected into 15-day old mice and injections either ceased on day 30 or continued to day 41. When CBE injection was stopped on day 30, mice were injected with phosphate buffered saline (PBS) until the end of the experiment. The number of mice used is shown. (B) Mouse weight. (C) GPNMB levels in the CSF (upper panel) and in the brain (lower panel) measured by ELISA. Results are means ± SEM. * p<0.06, ** p<0.01.