Flotillin-1 and flotillin-2 promoter activity is induced by Egr1, SRF and ERK2.

Flotillin promoter constructs F1-1330 (A, C, E) or F2-2130 (B, D, F) were cotransfected into Hela cells together with expression plasmids for Egr1, SRF, empty PSV control plasmid or with the ERK2 expression constructs, and the cells were lysed 48 h post-transfection. Relative luciferase activity of the control sample was set as 1. Values are mean ± standard deviation of at least 4 experiments measured in duplicates. ***p<0.001; **p<0.01; *p<0.05 vs. control.