Figure_2.tif (2.35 MB)
Expression of TLR4 and its endogenous ligands was upregulated in the early diabetic kidney in WT mice.
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posted on 2014-05-19, 03:23 authored by Jin Ma, Steven J. Chadban, Cathy Y. Zhao, Xiaochen Chen, Tony Kwan, Usha Panchapakesan, Carol A. Pollock, Huiling WumRNA expression of TLR4 and its ligands in kidney was upregulated at 10 weeks after diabetes induction (A & B). The data are presented as means ± SD; * p<0.05; ** p<0.01; *** p<0.001. n = 7 per group. (C) Representative sections of kidney were stained with a rabbit anti-mouse-TLR4 polyclonal antibody in the top panels and a goat anti-mouse-TLR4 polyclonal antibody in the bottom panels.
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cell biologySignal transductioncell signalingMembrane receptor signalingImmune receptor signalingImmunological signalingMolecular cell biologyMetabolic disordersDiabetes mellitusType 1 diabetestype 2 diabetesNephrologyChronic kidney diseaseModel organismsAnimal modelsMouse modelstlr4endogenousligandsupregulateddiabetickidneywt
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