Example illustrating the creation of the similarity network models.

In the similarity networks, the proteins that bind to ligands whose pairwise similarities exceed the Tc 0.7 cut-off value are connected. Therefore, we have two new connections in the similarity network: C and D are connected due to the similarity between lg2 and lg4, and A and C are connected due to the similarity between lg2 and lg3. The edge weights between nodes change depending on the weighting method used.