Evaluation of susceptibility of 2n, Ts and Tt mice to PTZ-induced seizure.

(a) Dose-response curves showing the ratio of the number of convulsing mice observed (obs) or predicted (pred) to the total number of injected animals for each PTZ dose. (b) Distributions of latencies of seizure for each genotype at the different doses of PTZ administered. (c) Global survival curves of 2n (blue), Ts (red) and Tt (green) mice (probability of seizure according to time, latencies right censored at 1800 sec).