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Effects of disruption of the LPS signaling pathway on counter-regulatory response to hypoglycemia.

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posted on 20.02.2013, 09:56 by James L. Young, Alfonso Mora, Anna Cerny, Michael P. Czech, Bruce Woda, Evelyn A. Kurt-Jones, Robert W. Finberg, Silvia Corvera

Norepinephrine levels in A) serum of wild type and CD14-ko 26 week old mice on ND following injection i.p. with insulin (1–1.5 U/kg body weight) *p<0.05, n = 6; B) urine collected over a 24 h period ***p<0.001, n = 8). C) Area under the curve of the glucose excursions for WT and CD14-ko mice following saline or propranolol (2 mg/kg of body weight) injection 30 minutes prior to insulin tolerance tests. **p<0.01 n = 4 for each group. Statistical differences were determined by student t-tests.