Effect of mepyramine and JNJ 7777120 on airway inflammation.

Mice were sensitized to, and provoked with, OVA and treated with DMSO, mepyramine, JNJ 7777120, or mepyramine plus JNJ 7777120 either 30 min before each provocation cycle (A, B) or 30 min before and 2 h after each injection for sensitization (C, D). A, C: Lungs were harvested, processed for histology, and sections were stained with H&E. Representative pictures are shown. B, D: Sections as represented in A, C were evaluated in a blinded fashion using an index scoring the grade of inflammation. (n_(sham) = 3, n_(DMSO) = 7, n_{(mepyramine, JNJ 7777120, or mepyramine+JNJ 7777120)} = 8; ***, p≤0.005).