Effect of carbenoxolone on 11β-HSD1 activity in WNIN/Ob lean and obese rats.
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posted on 2013-02-19, 18:30 authored by Siva Sankara Vara Prasad Sakamuri, Mahesh Sukapaka, Vijay Kumar Prathipati, Harishankar Nemani, Uday Kumar Putcha, Shailaja Pothana, Swarupa Rani Koppala, Lakshmi Raj Kumar Ponday, Vani Acharya, Giridharan Nappan Veetill, Vajreswari Ayyalasomayajula(A). Liver. (B). Subcutaneous adipose tissue. (C). Omental adipose tissue. (D). Skeletal muscle. 11β-HSD1 activity was measured after 1 h of subcutaneous injection of carbenoxolone or vehicle (50 mg/kg body weight/day). Empty bars indicate lean phenotype where as filled bars indicate obese phenotype. Values are means ± SEM for 6 animals for group. #p<0.05, ##p<0.01 and ### p<0.001 comparing vehicle-treated lean and obese rats. *p<0.05, **p<0.01 and *** p<0.001 comparing carbenoxolone-treated animals with vehicle-treated animals of the same phenotype.
