Effect of Netrin-1 on plasma cytokines level.

IL-1β, IL-6, TNF-α, and IL-10 plasma concentrations at the indicated times are shown for the normal group and AP groups with and without netrin-1 treatment. Acute pancreatitis was induced by two intraperitoneal injections of L-Arginine (4 g/kg, 1 h apart). Mice were treated with recombinant mouse netrin-1 at a dose of 1 µg/mouse or vehicle (0.1% BSA) immediately after the second injection of L-Arginine and every 24 h thereafter. Data are presented as mean±SD (n = 6 per group in the normal mice, n = 8 per group both in the AP model and netrin-1 treated AP model). ^*P<0.05.