Effect of LipESP on LPS-, IFN-γ-, or IFN-γ/LPS-induced cytokine production by human DCs.

Production of (a) IL-12p70, (b) IL-10 and (c) TNF-α were measured in DCs supernatant by ELISA after 48 h of stimulation by LipESP in presence or absence of LPS or IFN-γ or IFN-γ/LPS. Results are expressed as mean ± standard deviation (n = 10). * Statistically significant difference between non stimulated and LipESP-, LPS-, IFN-γ and IFN-γ/LPS-stimulated DCs (p<0·05); ** statistically significant difference between LPS-stimulated and LipESP/LPS-co-treated DCs (p<0·05); *** statistically significant difference between IFN-γ stimulated and LipESP/IFN-γ-co-treated DCs (p<0·05).