Effect of LZ-207 on the nuclear translocation of NF-κB p65 and on the phosphorylation of IκB and IKK in LPS-treated THP-1 cells.

(A-B) The nuclear and cytoplasmic extracts were separated and analyzed for NF-κB expression via Western blot. (C-F) Western blotting analysis of the phosphorylation of IκB and IKK in THP-1 cells treated with or without LZ-207 in the presence of LPS. The data are presented as the mean ± SD (n = 3). *P < 0.05, **P < 0.01, significant difference compared with the control.