Distribution of gene and interaction p-values for chain motifs.

Plot showing the distribution of minimum gene p-value versus minimum interaction p-value for each chain motif of length three, on a negative logarithmic scale. For clarity, only interactions with p< = 10−2 are shown. In order to deal with the considerable amount of overplotting due to the large number of data points with similar values, alpha transparency is used for color, resulting in darker colors in regions with many overlapping points. Histograms show the marginal distributions of the minimum gene / interactions p-values, respectively. The structure of the two outlier motifs containing the interaction IL7RJAK3 is also depicted. The gene / interaction corresponding to the values on the plot are indicated in red.