Figure_5.tif (9.26 MB)
Coronary artery atherosclerosis in 11-month-old LDLR−/−, LDLR +/−, and LDLR +/+ pigs fed a high fat, high cholesterol diet.
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posted on 2014-04-01, 03:19 authored by Bryan T. Davis, Xiao-Jun Wang, Judy A. Rohret, Jason T. Struzynski, Elizabeth P. Merricks, Dwight A. Bellinger, Frank A. Rohret, Timothy C. Nichols, Christopher S. RogersRepresentative H&E stained sections from each group are shown: LDLR−/− (A,B), LDLR +/− (C,D), and LDLR +/+ (E,F). Complex lesions were seen in the LDLR−/− pigs (A,B) that exhibited hemorrhage, possible areas of calcification, fibrous caps and foam cells.
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biotechnologycell biologyMolecular cell biologygeneticsGenetic dominanceAutosomal dominant diseasesFamilial hypercholesterolemiaAutosomal dominant traitsAnimal geneticsGenetics of diseaseHuman geneticsmolecular biologyMolecular biology techniquescloningOrganismal cloningVeterinary scienceAnimal typesLarge animalscardiologyVascular medicineatherosclerosisModel organismsAnimal modelsartery11-month-oldldlrpigsfed
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