Comparison of locus coeruleus (LC) distributions in control and mutant mice.

LC populations at post-natal day 30 (P30) and 90 (P90) for control mice (first column) and quaking mice (second column), and at P90 for control and quaking mice (third column). A–L: the central gray mesh represents the contour of a portion of the fourth ventricle. A–C: superimposed neuron positions (three mice in each group) for control mice at P30 (brown dots) and P90 (orange dots), and for quaking mice at P30 (dark blue dots) and P90 (light blue dots); black meshes: contours of the regions of interest (ROIs). D–L: comparison surfaces including positions where cell intensities were statistically greater in one group (), shown from the caudal (D–F), dorsal (G–I) and lateral (J–L) points of view; colors indicate the intensity-dominant group within the surface (same color code as for cells). M–O: coronal mid-sections through -maps, with ROI outlines in yellow. MN: lighter and darker gray levels correspond to positions with either an excess in P30 or in P90 cells, in control (M) or in mutant (N) mice, respectively. O: lighter or darker gray levels correspond to positions with either an excess in control or quaking cells, respectively. Scale bars: 400.