Figure_8.tif (1.33 MB)
Comparison of consensus frequencies inside and outside of epitopes.
figure
posted on 2010-08-20, 01:19 authored by Will Fischer, Vitaly V. Ganusov, Elena E. Giorgi, Peter T. Hraber, Brandon F. Keele, Thomas Leitner, Cliff S. Han, Cheryl D. Gleasner, Lance Green, Chien-Chi Lo, Ambarish Nag, Timothy C. Wallstrom, Shuyi Wang, Andrew J. McMichael, Barton F. Haynes, Beatrice H. Hahn, Alan S. Perelson, Persephone Borrow, George M. Shaw, Tanmoy Bhattacharya, Bette T. KorberChanges to consensus were much more frequent inside epitopes, and presumably these were rapidly selected for immune escape in part because they were relatively fit. Reversion to the consensus amino acids outside of the epitopes was never observed on the time scale studied here, but consensus forms were common by the time the subjects had reached chronic infection (RIER, shown here in green).
