Comparison of HRM diversity in women in the PEPI-Malawi trial and adults in the United States.

The figure compares HRM test results obtained for two groups: women in the PEPI-Malawi trial (PEPI, analyzed in this report) and adults in the United States (US, analyzed in a previous study [15]). Results from the PEPI-Malawi trial are shown for women identified as recently infected at enrollment using the MAA (MAA recent, N = 73), and women who were known to have non-recent HIV infection at enrollment (known non-recent, N = 54); these data were obtained by testing samples collected at the time of study enrollment. Results from adults in the US are shown for adults with known recent HIV infection (N = 102, samples collected at the time of HIV seroconversion, median time since last negative HIV test: 189 days, range 14–540 days) and adults with known non-recent HIV infection (N = 67, known to be infected for 2 years or more, including 32 with CD4 cell counts <50 cells/mm³ and 30 on antiretroviral therapy) [15]. P values were calculated using the Wilcoxon rank sum test.