Comparison between synthetic passenger mutations (PMs) and real PMs.

Plotted are the Mutation Assessor variant specificity scores of sets of synthetic PMs (generated by CHASM), CCLE PMs, TCGA PMs and driver mutations from the 4 test sets in Table 1, for GBM (a) and OVC (b), respectively. Significant differences (Mann-Whitney U test) between two score distributions are indicated with P values reported.