Fig_6.tif (2.36 MB)
Codons under positive diversifying selection encode amino acid residues at the ROP5BI /IRGa6 interface.
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posted on 2015-08-20, 03:46 authored by Michael S. Behnke, Asis Khan, Elvin J. Lauron, John R. Jimah, Qiuling Wang, Niraj H. Tolia, L. David Sibley(A) Structure of T. gondii ROP5BI (grey) bound to murine Irga6 (tan) showing amino acid residues under positive diversifying selection (red), ROP5BI residues at the ROP5BI /Irga6 interface (blue), and residues that are under positive diversifying selection and at the interface (purple). (B) Both panels are a rotation of 60° about the x-axis with respect to A, showing ROP5BI with Irga6 removed for clarity. The color scheme is as in A. Bottom panel is a surface representation showing the overlap in surface residues. The top panel shows the position of all amino acid residues under positive diversifying selection.
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type 8 TgCtBr 5type 1 parasiteshost immunity factorsxiiSouth American strainsvirulence factor accountingVirulence factorsRhoptry Proteins ROP 5ROP 5North American type 2South American type 10 VAND strainqtlROP 18Toxoplasma gondii Toxoplasma gondiiROP 18 functionROP 5 locustype 10 strainsMajor Murine Virulence FactorsROP 18 knockoutsQuantitative trait locustype 4 TgCtBr 18 strains
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