Classical MHC-I molecules are involved in selective killing inhibition of NKL cells triggered by CD16 and NKp46 activating receptors.

(A) Classical and non-classical MHC-I expression on NKL cells. Filled histograms represent isotype control and open histograms represent surface receptor stained cells. (B) Exponentially growing NKL cells were co-cultured with ⁵¹Cr-P815 cells at 5∶1 E/T ratio in the presence of mAb against KAR (CD16 (a), NKG2D (b) or NKp46 (c)), plus control Ig, or different anti-MHC-I mAb (W6/32, BB7.7 or HLA-E clone 3D12). One representative experiment (n = 3) is shown.