Chemosensitive MC1 transplanted in fat pad of SCID Beige mice, with non-significant decrease in TIC markers (ALDF, CD44+/CD24−, and MSFE) with Stat3 inhibitor compared to chemotherapy alone.
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posted on 2012-08-06, 01:32 authored by Bhuvanesh Dave, Melissa D. Landis, Lacey E. Dobrolecki, Meng-Fen Wu, Xiaomei Zhang, Thomas F. Westbrook, Susan G. Hilsenbeck, Dan Liu, Michael T. Lewis, David J. Tweardy, Jenny C. Chang(A) Tumor volume fold change over time (14 days). Decrease in mean tumor volume + SEM was observed with chemotherapy alone (chemosenstive tumor line). (B) FACS analysis of 100,000 cells MC1 tumor cells for CD44+/CD24−, ALDF. Data were depicted as Mean + SEM. Non-significant decrease in TIC markers (ALDF, CD44+/CD24) with Stat3 inhibitor compared to chemotherapy alone was observed. (C) Mammosphere forming efficiency of tumor cells seeded at 10,000 cells/ml. Data depicted as Mean + SEM. Non-significant decrease in MSFE with C188 compared to chemotherapy alone was observed.
