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Causal network to depict functional relations between sensitivity-specific and resistance-specific signature genes.
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posted on 2015-06-24, 04:31 authored by Bin Li, Hyunjin Shin, Georgy Gulbekyan, Olga Pustovalova, Yuri Nikolsky, Andrew Hope, Marina Bessarabova, Matthew Schu, Elona Kolpakova-Hart, David Merberg, Andrew Dorner, William L. TrepicchioThe network was reconstructed from canonical signaling pathways regulated by signature genes and a signature specific direct interaction network. Sensitivity-specific signature genes are highlighted with blue thermometers, resistance-specific genes with red thermometers.
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patient datadrug discoverytreatment armssignature genestrial designPredict Treatment Outcomedrug sensitivity modelscancer indicationsstage trialstrial resultssplitting strategypatient stratificationpatient inclusion parametercanonical pathwaysGEO expression datasetserlotinibIdentify Cell Line Derived Translational Biomarkersplsrmodeling frameworkSorafenib Developmentmodel buildingSuch translational biomarkerssquares regressiontrial phases
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