CONSORT Flow Chart Describing Patients Enrolled in Randomized Clinical Trials at St. Jude Children's Research Hospital, from Which the Current Study Population Was Derived

The flow chart includes study relevant protocol information for the St. Jude Children's Research Hospital Total Therapy Protocols XIIIA, XIIIB, and XV. Specifically, from the population that received ALL treatment according to one of these three protocols, the current study included only patients who received HDMTX as initial therapy. These protocols included a randomization to determine whether patients received HDMTX or not as initial treatment, the infusion time of HDMTX, and whether MP was given after MTX (LDMTX, low-dose methotrexate). Patients with an insufficient number of ALL cells for gene expression analysis were excluded, as were patients with insufficient data on circulating ALL cells to assess response over 3 d.