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Biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

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posted on 2014-04-21, 09:39 authored by David T. Fox, Emily N. Schmidt, Hongzhao Tian, Suraj Dhungana, Michael C. Valentine, Nicole V. Warrington, Paul D. Phillips, Kellan B. Finney, Emily K. Cope, Jeff G. Leid, Charles A. Testa, Andrew T. Koppisch

IPP and DMAPP are formed through the mevalonate pathway (left) in mammals, fungi and plants and through the methylerythritol phosphate (MEP) pathway (right) in many bacteria, green algae, and plant chloroplasts. Fosmidomycin inhibits formation of IPP and DMAPP (and thus late stage isoprenoid compounds) through disruption of the MEP pathway.

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    BiochemistrymetabolismMetabolic pathwaysmicrobiologyMedical microbiologyMicrobial pathogensBacterial pathogensSalmonellaMicrobial physiologyMicrobial metabolismMicrobial controlClinical medicineInfectious diseasesInfectious disease controlpharmacologyDrug research and developmentisopentenyldiphosphatedimethylallyl

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