Figure_7.tif (2.03 MB)
Bioinformatical network analysis for S100.
figure
posted on 2012-12-20, 00:49 authored by Christin Klenke, Sebastian Janowski, Daniela Borck, Darius Widera, Jörg Ebmeyer, Jörn Kalinowski, Anke Leichtle, Ralf Hofestädt, Tahwinder Upile, Christian Kaltschmidt, Barbara Kaltschmidt, Holger SudhoffProteins are the nodes and the edges are protein activation/inactivations, such as phosphorylation and dephosphorylation across a set of proteins. The S100 Network shows an up-regulation of S100A7, S100A8 and S100A9 as well as ILK and IκB, USF2 and ARRB2. In which NUAK1 seems to be down-regulated. Different colors showing the expression of genes with the cholesteatoma compared to external auditory skin: red: up-regulated; green: down-regulated; grey: the gene for the protein is not in the microarray; Node-Size also called “Node Ranking” describes the number of interactions. The bigger the nodes, the more interactions are represented for the protein in the network.