Behavioral data of rats that underwent partial ligation of the proximal sciatic nerve (Seltzer model).

(A) Combined results of the von Frey withdrawal thresholds and hotplate latencies, at baseline and 10, 12 and 14 days after nerve ligation, from al 18 rats in the study, demonstrating tactile and thermal hyperalgesia. Error bars indicate SEM. p<0.01; repeated measures ANOVAs, source of variation timepoint; ***p<0.01; pairwise comparisons of day 0 versus day 10, 12 and 14, using Bonferroni correction. (B,C) Von Frey withdrawal thresholds (B) and hotplate latencies (C) from 7 neuropathic rats that subsequently underwent SCS and 6 neuropathic rats that subsequently underwent sham stimulation, demonstrating a similar degree of tactile and thermal hyperalgesia in both groups. Error bars indicate SEM. p>0.06; repeated measures ANOVAs, source of variation treatment.