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Axon counts and demonstration of myelinated of myelinated profiles proximal and distal to either the autologous transplanted nerve or the implanted spider silk construct.

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posted on 2013-02-20, 20:17 authored by Christine Radtke, Christina Allmeling, Karl-Heinz Waldmann, Kerstin Reimers, Kerstin Thies, Henning C. Schenk, Anja Hillmer, Merlin Guggenheim, Gudrun Brandes, Peter M. Vogt

(A) Axon counts lesion site and at regions proximal and distal were compared between both groups. Plastic embedded coronal sections of autologous nerve transplant (B and D) and spider silk construct (C and E) at 10 months post surgery. The improved organization of myelinated axons after transplantation of the spider silk construct could be demonstrated by light (C) and transmission electron microscope (E). All spider fibers were degraded in a subtle manner, since an inflammation has never been seen. Scale bar for C and D in D = 3 µm, for E and F in F = 1 µm.

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