Assessment of tissue specific insulin sensitivity by hyperinsulinemic-euglycemic clamp, comparison between ten days T2 treatment (n = 10) vs. vehicle (n = 8).

A. Plasma glucose and B. glucose infusion rate during hyperinsulinemic-euglycemic clamp (circles = vehicle treatment; squares = T2 treatment). C. Endogenous glucose production under basal conditions (white bars = vehicle; black bars = T2). D. Percent suppression of endogenous glucose production by insulin (4 mU/kg-min). E. Whole body insulin-stimulated glucose disposal.