Apoptosis of a peripheral cell.

(a) A small tissue before the labeled red cell proceeds to apoptosis. (b) The tissue after the demise of the red cell. The black arrow points to the location where the red cell was. The apoptosis of the red cell caused significant changes on its neighboring cells (labeled 1 and 2). A larger tissue before (c) and after (d) the labeled red cell proceeds to apoptosis. The black arrow in (d) points to the location where the red cell was apoptosized.