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Aortic dilatation in Marfan mice reduced by losartan.

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posted on 2014-09-19, 02:51 authored by Romy Franken, Stijntje Hibender, Alexander W. den Hartog, Teodora Radonic, Carlie J. M. de Vries, Aeilko H. Zwinderman, Maarten Groenink, Barbara J. M. Mulder, Vivian de Waard

The aortic root dilatation rate was determined. Placebo-treated Marfan mice had a significantly higher dilatation rate compared to wildtype mice. Losartan attenuated the aortic root dilatation rate in Marfan mice significantly, whereas the other treatment strategies did not change the aortic root dilatation rate compared to placebo-treated Marfan mice.

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    losartan decreases aortic root dilatationFBN 1C Marfan mouse modelincrease aortic damageFBN 1C Marfan miceaortic root dilatationaortic root dilatation rateattenuating aortic root dilationtest novel treatment strategiesangiotensin II receptor type 1Marfan syndromeaortic dilatation rateMarfan Mice AimsPatientstgfadult Marfan mice

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