Analysis of favorable and unfavorable contributions to intramolecular HINT score:

CNS+HINT refined structure models. (A) Favorable (blue, hydrogen bond and acid-base) and unfavorable (red, acid-acid and base-base) contributions to polar interaction component of HINT score. (B) Favorable (green, hydrophobic-hydrophobic) and unfavorable (violet, hydrophobic-polar) contributions to hydrophobic interaction component of HINT score.