Figure_1.tif (2.72 MB)
Agonist-selective internalization of human somatostatin receptors.
figure
posted on 2012-06-26, 02:19 authored by Andrea Kliewer, Anika Mann, Aline Petrich, Florian Pöll, Stefan SchulzHEK293 cells stably expressing sst2, sst3 or sst5 receptors were treated with either 1 µM SS-14, octreotide, pasireotide or somatoprim for 0 or 30 min. Cells were fixed, immunoflurescently stained with anti-sst2 {UMB-1}, anti-sst3 {UMB-5} or anti-sst5 {UMB-4} antibodies, and examined by confocal microscopy. Shown are representative images from one of three independent experiments performed in duplicate. Scale bar, 20 µm.