Acute, first window RIC activates autophagy signaling via p-AMPK upregulation and concomitant downregulation of mTOR.

(A) Western blots for autophagy related signaling proteins. (B) Quantification of the protein fold change in 1W RIC compared to 1W controls. Values are means ± S.E.M. n = 6–8 per group. An (*) denotes a statistically significant difference (P<0.05) compared to control. (P-: phospho-).