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Ablation of PTP1B increases proliferation in in vitro transfected MIN6 cells and dispersed islet cells.
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posted on 2014-02-28, 04:03 authored by Rebeca Fernandez-Ruiz, Elaine Vieira, Pablo M. Garcia-Roves, Ramon GomisA) mRNA expression and B) protein content are used to confirm the efficiency of PTP1B siRNA transfection and silencing in MIN6 cells. Values are expressed relative to 36B4 as a housekeeping gene and actin protein content respectively. C) In vitro BrdU incorporation in proliferating si-ptpn1 MIN6 cells. Represented values are normalized to scrambled siRNA (Sc) MIN6 cells; n = 3 different experiments, 10 replicates per group each experiment. D) In vitro BrdU incorporation in PTP1B −/− proliferating dispersed islet cells is expressed relative to WT; n = 3 different experiments, 6 replicates per group each experiment. All bars represent mean±SEM * p<0.05, ** p<0.005 PTP1B −/− vs WT.
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BiochemistrymetabolismMetabolic pathwayshormonesModel organismsAnimal modelsmouseMolecular cell biologySignal transductionSignaling cascadesAkt signaling cascadeERK signaling cascadeSignaling in cellular processesSTAT signaling familyEndocrinologyDiabetic endocrinologyDiabetes mellitus type 2Endocrine physiologyEndocrine cellsinsulinptp1bproliferationtransfectedmin6cellsdispersedislet
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