Figure_6.tif (553.87 kB)
A schematic representation of the interaction between mutant p53 and the IFNβ pathway.
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posted on 2013-04-22, 02:10 authored by Shalom Madar, Einav Harel, Ido Goldstein, Yan Stein, Ira Kogan-Sakin, Iris Kamer, Hilla Solomon, Elya Dekel, Perry Tal, Naomi Goldfinger, Gilgi Friedlander, Varda RotterBlue arrows denote positive effect while red arrows denote negative effect. Upon encounter with cancer cell CAFs activate the IFNβ pathway which limits cancer cells' migration. When mutant p53 is present in the cancer cells, this pathway is moderated via SOCS1 mediated inhibition of STAT1 phosphorylation. IFNβ is able to reduce mutant p53 RNA levels by attenuating the expression of mutant p53 RNA stabilizer WIG1.
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geneticsgene expressionDNA transcriptionRNA stabilityCancer geneticsGene networksGenetic mutationGenetics of diseaseimmunologyImmunologic subspecialtiesTumor immunologyMolecular cell biologySignal transductionSignaling in cellular processesAntiapoptotic signalingSignaling in selected disciplinesOncogenic signalingClinical immunologyoncologyCancers and neoplasmsLung and intrathoracic tumorsAdenocarcinoma of the lungschematicmutantp53
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