Figure_10.tif (1.89 MB)
A schematic diagram of our hypothesis: endurance exercise up-regulates Kir6.1 and shortens tissue oxygenation recovery time.
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posted on 2014-12-04, 02:44 authored by Yuanjing Li, Ming Cai, Li Cao, Xing Qin, Tiantian Zheng, Xiaohua Xu, Taylor M. Sandvick, Kirk Hutchinson, Loren E. Wold, Keli Hu, Qinghua Sun, D. Paul Thomas, Jun Ren, Guanglong HeDuring ischemia and at the beginning of reperfusion, the relatively high level of the ADP/ATP opens the VSMC sarc-KATP channels, leading to hyperpolarization of the VSMC membrane and dilation of the coronary vasculature. Kir6.1-induced transient vasodilation shortens reperfusion recovery time τ and contributes to exercise-induced protection of myocytes from I/R injury.
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Mice Exercise training57BLreperfusionexerciseWestern immunoblotting analysesischemia reperfusion injuryprotectiontissue oxygenation recoveryKir 6.1AAAinjuryoximetryEndurance Exercise Accelerates Myocardial Tissue Oxygenation Recoverytissue oxygenation recovery timevsmcmintransfectionvivo gene transfer
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