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A generalized drawing of a cytoplasmic cape.

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posted on 2014-04-04, 03:14 authored by Juan Wu, Katelyn J. Bakerink, Meagan E. Evangelista, Graham H. Thomas

All wild-type capes have two regions: (1) A complex area of membrane folding at the nuclear periphery that contains abundant perinuclear vesicles. These vesicles are bound by a single membrane and separated from the nucleoplasm by a single membrane bilayer; (2) A terminal chamber where the two membrane bilayers separate single membrane bound organelles and granules (with no obvious membrane layer) from the nucleoplasm. The universal juxtaposition of these two regions seen by extensive serial sectioning leads us to hypothesize that their formation and perhaps function is linked. Blue line – Outer nuclear membrane; Red line – inner nuclear membrane.

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